MicroRNAs and genes proposed as CVD biomarkers may be used to develop new diagnostic and therapeutic methods.Ĭhronic Venous Disease (CVD) is a common vascular disease of the lower limbs. The study shed new light on miRNA-dependent regulatory mechanisms involved in the pathology of CVD. Functional analysis of microRNA-regulated genes revealed terms closely related to cardiovascular diseases and risk factors. Regulatory interactions between potential biomarker miRNAs and genes were projected.
Thirty-one miRNAs and 62 genes were recognized as potential biomarkers of CVD using DESeq2, Uninformative Variable Elimination by Partial Least Squares (UVE-PLS) and ROC (Receiver Operating Characteristics) methods.
Using next generation sequencing, miRNA and gene expression profiles in peripheral blood mononuclear cells of subjects with CVD in relation to healthy controls were studied. The aim of the study was to analyze alterations of miRNA and gene expression in CVD, as well as to identify miRNA-mediated changes in gene expression and their potential link to CVD development. These processes are partly regulated by microRNA (miRNA)-dependent modulation of gene expression, pointing to miRNA as a potentially important target in diagnosis and therapy of CVD progression. Pathologic features include varicose veins, venous valves dysfunction and skin ulceration resulting from dysfunction of cell proliferation, apoptosis and angiogenesis. Chronic venous disease (CVD) is a vascular disease of lower limbs with high prevalence worldwide.
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